9,10-Phenanthrenequinone

9,10-Phenanthrenequinone is an inhibitor of claudin-5/CLDN5 that induces apoptosis via a NO synthase/ROS-dependent mechanism. 9,10-Phenanthrenequinone also promotes endothelial barrier dysfunction by promoting caspase activation and DNA fragmentation, and reducing CLDN5 expression and proteasomal proteolysis[1].

Product Specifications

CAS Number

[84-11-7]

UNSPSC

12352005

Hazard Statement

H319, H400

Target

Claudin

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.95

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=CC=CC=C2C3=CC=CC=C3C1=O

Molecular Formula

C14H8O2

Molecular Weight

208.21

Precautions

H319, H400

References & Citations

[1]Kamase K, et al. 9,10-Phenanthrenequinone provokes dysfunction of brain endothelial barrier through down-regulating expression of claudin-5. Toxicology. 2021 Sep;461:152896.