PKC-IN-6

PKC-IN-6 (Compound 21) is a selective inhibitor of tyrosine and serine kinases. PKC-IN-6 shows inhibitory activity against PKC-α, PKC-δ, PKA, EGF-R with IC50 values of 240, >500, >500, >100 μM, respectively. PKC-IN-6 is promising for research of cancers[1].

Product Specifications

CAS Number

[152460-10-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR; PKA; PKC; Ser/Thr Kinase; Tyrosinase

Related Pathways

Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Concentration

10mM

Purity

99.93

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=CC(=C(C=C1)C)NC2=NC=CC(=N2)C3=CC=CN=C3

Molecular Formula

C16H15N5

Molecular Weight

277.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Zimmermann J, et al. Phenylamino-pyrimidine (PAP) derivatives: a new class of potent and selective inhibitors of protein kinase C (PKC) . Arch Pharm (Weinheim) . 1996 Jul;329 (7) :371-6.