Inosine-5'-diphosphate (disodium)
Inosine-5'-diphosphate disodium (IDP disodium) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM) . Inosine-5'-diphosphate disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate disodium can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research[1][2][3].
Product Specifications
CAS Number
54735-61-4
Product Name Alternative
IDP (disodium) ; Inosine-5'-diphosphoric acid (disodium)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; c-Myc
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Purity
99.08
Solubility
H2O : 175 mg/mL (ultrasonic)
Smiles
O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3)C=N2)NC=N1
Molecular Formula
C10H14N4O11P2
Molecular Weight
428.19
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Frequently Asked Questions
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