Inosine-5'-diphosphate (disodium)

Inosine-5'-diphosphate disodium (IDP disodium) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM) . Inosine-5'-diphosphate disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate disodium can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research[1][2][3].

Product Specifications

CAS Number

[54735-61-4]

Product Name Alternative

IDP (disodium) ; Inosine-5'-diphosphoric acid (disodium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; c-Myc

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Purity

99.08

Solubility

H2O : 175 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3)C=N2)NC=N1

Molecular Formula

C10H14N4O11P2

Molecular Weight

428.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Sengupta P, et al. Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding. Biochim Biophys Acta Gen Subj. 2020 Sep;1864 (9) :129649. |[2]Sokolov I K, et al. Adaptogenic effect of riboxin[J]. Pharmaceutical Chemistry Journal, 1980, 14 (1) : 34-39.|[3]Veveris M, et al. Experimental study of the antiarrhythmic effect of riboxin. Farmakol. Neirotropnykh Sredstv (1978), 119-24.