2-Ketoglutaric acid (Sodium) (GMP)

2-Ketoglutaric acid (Alpha-Ketoglutaric acid) Sodium (GMP) is 2-Ketoglutaric acid Sodium (HY-W013636A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 2-Ketoglutaric acid Sodium is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM) [1].

Product Specifications

CAS Number

[22202-68-2]

Product Name Alternative

Alpha-Ketoglutaric acid (Sodium) (GMP)

UNSPSC

12352211

Target

Endogenous Metabolite; Tyrosinase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Neurological Disease

Smiles

O=C(O[Na])C(CCC(O)=O)=O

Molecular Formula

C5H5NaO5

Molecular Weight

168.08

References & Citations

[1]Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79 (4) :419-35. |[2]Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105 (Pt 3) :1654-1662.