2′-Deoxy-GDP (trisodium)

2′-Deoxy-GDP (dGDP) trisodium, a guanosine monophosphate (GMP) analogue, is a hypoxanthine phosphoribosyltransferase (HGPRT) inhibitor with an IC50 of 12.5 μM. HGPRT is a central enzyme in the purine recycling pathway of all protozoan parasites[1].

Product Specifications

CAS Number

[102783-74-4]

Product Name Alternative

DGDP (trisodium) ; 2'-Deoxyguanosine-5'-diphosphate (trisodium)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Nucleoside Antimetabolite/Analog; Parasite

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Purity

98.78

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O[C@H]1C[C@H](N(C=N2)C3=C2C(N=C(N)N3)=O)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O[Na])=O

Molecular Formula

C10H12N5Na3O10P2

Molecular Weight

493.15

Precautions

H315, H319, H335

References & Citations

[1]Md Yousuf Ansari, et al. Establishment of correlation between in-silico and in-vitro test analysis against Leishmania HGPRT to inhibitors. Int J Biol Macromol. 2016 Feb:83:78-96.