2,5-Di-tert-butylhydroquinone (Standard)

2,5-Di-tert-butylhydroquinone (Standard) is the analytical standard of 2,5-Di-tert-butylhydroquinone. This product is intended for research and analytical applications. 2,5-Di-tert-butylhydroquinone (BHQ) (Compound 2), an indirect food additive, is a Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor with an IC50 of 400 nM. 2,5-Di-tert-butylhydroquinone disrupts the gating function of the residue Glu309 which prevents Ca2+ from reaching their binding site. 2,5-Di-tert-butylhydroquinone regulates the activity of 5-lipoxygenase and COX-2 (IC50: 1.8 and 14.1 μM for 5-LO and COX-2, respectively) [1][2].

Product Specifications

CAS Number

[88-58-4]

UNSPSC

12352005

Target

Calcium Channel; COX; Lipoxygenase; Reference Standards

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology

Smiles

OC1=CC(C(C)(C)C)=C(O)C=C1C(C)(C)C

Molecular Formula

C14H22O2

Molecular Weight

222.33

References & Citations

[1]Zsofia Kutil, et al. The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro. Food and Agricultural Immunology. Volume 26, 2015-Issue 4.|[2]Kempton RJ, et al. Heck- and Suzuki-coupling approaches to novel hydroquinone inhibitors of calcium ATPase. Beilstein J Org Chem. 2019 Apr 24;15:971-975.