4-Chloro-3-sulfamoylbenzoic acid

4-Chloro-3-sulfamoylbenzoic acid is an inhibitor of human carbonic anhydrase, targeting the cytosolic isoforms hCA I and hCA II (glaucoma-associated), and the transmembrane isoforms hCA IV and hCA IX (tumor hypoxia-induced) [1].

Product Specifications

CAS Number

[1205-30-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Carbonic Anhydrase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Purity

99.97

Smiles

ClC1=C(S(N)(=O)=O)C=C(C(O)=O)C=C1

Molecular Formula

C7H6ClNO4S

Molecular Weight

235.64

Precautions

H315, H319, H335

References & Citations

[1]Swain B, et al. Synthesis of a new series of 3-functionalised-1-phenyl-1,2,3-triazole sulfamoylbenzamides as carbonic anhydrase I, II, IV and IX inhibitors. J Enzyme Inhib Med Chem. 2019 Dec;34 (1) :1199-1209.