3,4,5-Trimethoxycinnamic acid (Standard)
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
Product Specifications
CAS Number
90-50-6
UNSPSC
12352005
Target
Endogenous Metabolite; GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
COC1=C(OC)C(OC)=CC(/C=C/C(O)=O)=C1
Molecular Formula
C12H14O5
Molecular Weight
238.24
References & Citations
[1]Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji) . Biol Pharm Bull. 2004 Aug;27 (8) :1317-9.|[2]Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36 (10) :1244-51.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC680994-500 1x 500 µL
TNF alpha (J2D10), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470226-100 1x 100 µL
Pmel17 / gp100 / SILV (NKI-beteb), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401683-500 1x 500 µL
Factor XIIIa (Coagulation Factor XIIIA Chain) (F13A1/1683), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC682386-500 1x 500 µL
CD14 (Monocyte / Macrophage Marker) (LPSR/2386), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881864-500 1x 500 µL
AMACR / p504S (Prostate Cancer Marker) (AMACR/1864), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details