DMBA (Standard)
DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH) . DMBA is used to induce tumor formation in various rodent models[1].
Product Specifications
CAS Number
57-97-6
UNSPSC
12352005
Hazard Statement
H302-H350
Target
C-Myc
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
CC(C1=CC=CC=C21)=C3C=CC4=CC=CC=C4C3=C2C
Molecular Formula
C20H16
Molecular Weight
256.35
Precautions
P264-P270-P280-P405-P501
References & Citations
[1]Csiszar A, Balasubramanian P, Tarantini S, Yabluchanskiy A, Zhang XA, Springo Z, Benbrook D, Sonntag WE, Ungvari Z. Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research. Geroscience. 2019 Apr;41 (2) :209-227. |[2]HUGGINS C, et al., Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression. Nature. 1961 Jan 21;189:204-7.|[3]Goerttler K, et al., Skin tumor formation in the European hamster (Cricetus cricetus L.) after topical initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA) . Carcinogenesis. 1984 Apr;5 (4) :521-4.|[4]Saini RK, et al., Pulmonary carcinogenesis in mice with a single intratracheal instillation of 9, 10-dimethyl benz[a]anthracene. Drug Chem Toxicol. 2008;31 (4) :459-71.|[5]Gao J, et al., Microsomal expoxide hydrolase is required for 7,12-dimethylbenz[a]anthracene (DMBA) -induced immunotoxicity in mice. Toxicol Sci. 2007 Jul;98 (1) :137-44.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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