7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters[1], which are capable of forming covalent DNA adducts and inducing mutations[2].

Product Specifications

CAS Number

[6272-55-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H332, H335

Target

Biochemical Assay Reagents

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.09

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OC1CCCC2=C3C=CC4=CC=CC5=C4C3=C(C=C21)C=C5

Molecular Formula

C20H16O

Molecular Weight

272.35

Precautions

H302, H315, H319, H332, H335

References & Citations

[1]Glatt H, Pauly K, Frank H, Seidel A, Oesch F, Harvey RG, Werle-Schneider G. Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat. Carcinogenesis. 1994 Nov;15 (11) :2605-11.|[2]Surh YJ, Tannenbaum SR. Sulfotransferase-mediated activation of 7,8,9,10-tetrahydro-7-ol, 7,8-dihydrodiol, and 7,8,9,10-tetraol derivatives of benzo[a]pyrene. Chem Res Toxicol. 1995 Jul-Aug;8 (5) :693-8.