Geranylgeraniol-d5

Geranylgeraniol-d5 is the deuterium labeled Geranylgeraniol (HY-W011474) . Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model[1][2][3][4].

Product Specifications

CAS Number

[174873-05-3]

UNSPSC

12352211

Target

Isotope-Labeled Compounds; NF-κB

Related Pathways

NF-κB; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C([2H])([2H])[2H])=C/C([2H])([2H])O

Molecular Formula

C20H29D5O

Molecular Weight

295.51

References & Citations

[1]Saputra WD, et al. Geranylgeraniol Inhibits Lipopolysaccharide-Induced Inflammation in Mouse-Derived MG6 Microglial Cells via NF-κB Signaling Modulation. Int J Mol Sci. 2021 Sep 29;22 (19) :10543. |[2] Marcuzzi A, et al. Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology. Int J Mol Sci. 2016 Mar 11;17 (3) :365. |[3] Preece K, et al. A toxicological evaluation of geranylgeraniol. Regul Toxicol Pharmacol. 2021 Aug;124:104975. |[4] Giriwono PE, et al. Dietary supplementation with geranylgeraniol suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats. Eur J Nutr. 2013 Apr;52 (3) :1191-9.