Geranylgeraniol-d5
Geranylgeraniol-d5 is the deuterium labeled Geranylgeraniol. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model[1][2][3][4].
Product Specifications
CAS Number
174873-05-3
UNSPSC
12352211
Target
Isotope-Labeled Compounds; NF-κB
Related Pathways
NF-κB; Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C([2H])([2H])[2H])=C/C([2H])([2H])O
Molecular Formula
C20H29D5O
Molecular Weight
295.51
References & Citations
[1]Saputra WD, et al. Geranylgeraniol Inhibits Lipopolysaccharide-Induced Inflammation in Mouse-Derived MG6 Microglial Cells via NF-κB Signaling Modulation. Int J Mol Sci. 2021 Sep 29;22 (19) :10543. |[2] Marcuzzi A, et al. Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology. Int J Mol Sci. 2016 Mar 11;17 (3) :365. |[3] Preece K, et al. A toxicological evaluation of geranylgeraniol. Regul Toxicol Pharmacol. 2021 Aug;124:104975. |[4] Giriwono PE, et al. Dietary supplementation with geranylgeraniol suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats. Eur J Nutr. 2013 Apr;52 (3) :1191-9.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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