2'-Deoxyuridine 5'-monophosphate (disodium) (Standard)
2'-Deoxyuridine 5'-monophosphate (disodium) (Standard) is the analytical standard of 2'-Deoxyuridine 5'-monophosphate (disodium). This product is intended for research and analytical applications. 2'-Deoxyuridine 5'-monophosphate (dUMP) disodium is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis[1].
Product Specifications
CAS Number
42155-08-8
Target
Endogenous Metabolite; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Infection; Metabolic Disease
Smiles
O[C@H]1C[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O[Na])(O[Na])=O
Molecular Formula
C9H11N2Na2O8P
Molecular Weight
352.15
References & Citations
[1]Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP) -binding Tyr-261. Biochemistry. 2006 Jun 20;45 (24) :7415-28.|[2]Skouloubris S, et al. Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones. Open Biol. 2015 Jun;5 (6) :150015.|[3]Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP) -binding Tyr-261. Biochemistry. 2006 Jun 20;45 (24) :7415-28.|[4]Skouloubris S, et al. Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones. Open Biol. 2015 Jun;5 (6) :150015.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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