Win 18446 (Standard)
Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid biosynthesis from Retinol (HY-B1342) within the testes[1][2].
Product Specifications
CAS Number
1477-57-2
UNSPSC
12352211
Target
Aldehyde Dehydrogenase (ALDH)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Endocrinology
Smiles
O=C(NCCCCCCCCNC(C(Cl)Cl)=O)C(Cl)Cl
Molecular Formula
C12H20Cl4N2O2
Molecular Weight
366.11
References & Citations
[1]John K Amory, et al. Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J Androl. Jan-Feb 2011;32 (1) :111-9.|[2]Cathryn A Hogarth, et al. Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol Reprod. 2011 May;84 (5) :957-65.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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