What is the catalog number for SC-236 (Standard)?

The catalog number for SC-236 (Standard) is HY-W010983R.

What sizes are available for SC-236 (Standard)?

SC-236 (Standard) is available in the following size(s): 1 Each.

Is SC-236 (Standard) in stock?

SC-236 (Standard) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SC-236 (Standard)?

SC-236 (Standard) is manufactured by QuantiMol.

What is the estimated delivery time for SC-236 (Standard)?

Estimated delivery time for SC-236 (Standard) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for SC-236 (Standard)?

The safety data sheet for SC-236 (Standard) is available here: http://file.medchemexpress.com/batch_PDF/HY-W010983R/.

SC-236 (Standard)

SC-236 is an orally active COX-2 specific inhibitor (IC50 = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model[1][2][3][4][5].

Product Specifications

CAS Number

170569-86-5

UNSPSC

12352005

Target

Apoptosis; COX; PPAR

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Smiles

O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC=C(Cl)C=C3)C=C1)(N)=O

Molecular Formula

C16H11ClF3N3O2S

Molecular Weight

401.79

References & Citations

[1]Shao-Yu Fang, et al. Reduction in MicroRNA-4488 Expression Induces NFκB Translocation in Venous Endothelial Cells Under Arterial Flow. Cardiovasc Drugs Ther. 2020 Sep 9.|[2]Anna Planagumà, et al. The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. FASEB J. 2005 Jul;19 (9) :1120-2.|[3]Benjamin Chun-Yu Wong, et al. Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase. Gastroenterology. 2004 Jan;126 (1) :136-47.|[4]Su-Jin Kim, et al. The COX-2 inhibitor SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model. Life Sci. 2007 Aug 23;81 (11) :863-72.|[5]T D Penning, et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5- (4-methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib) . J Med Chem. 1997 Apr 25;40 (9) :1347-65.