Uridine-5'-diphosphate disodium salt (Standard)

Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor) . Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].

Product Specifications

CAS Number

[27821-45-0]

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; P2Y Receptor

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Inflammation/Immunology

Smiles

O[C@H]1[C@H](N(C=CC2=O)C(N2)=O)O[C@H](COP(OP(O)(O[Na])=O)(O[Na])=O)[C@H]1O

Molecular Formula

C9H12N2Na2O12P2

Molecular Weight

448.12

References & Citations

[1]Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5 (1) :75-89.|[2]Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186 (6) :3701-9.|[3]Edyta Gendaszewska-Darmach, et al. Nucleoside 5'-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation. Oncotarget. 2016 Oct 25;7 (43) :69358-69370.|[4]Zainab S B Abbas, et al. UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery. Vascul Pharmacol. 2018 Apr;103-105:36-46.