Meso-tetraphenylchlorin
Meso-tetraphenylchlorin (TPCS2a) is a photosensitizer with poor water solubility, which limits its use in the blood circulation. However, TPCS2a@NPs nanoparticles can be prepared based on polylactic-co-polyethylene glycol acid (PLGA) polymer core loaded with TPCS2. Such nanoparticles can be coated with mesenchymal stem cell-derived plasma membranes (mMSCs) to form mMSC-TPCS2a@NPs, which prolongs blood circulation time and improves tumor targeting ability. Compared with uncoated TPCS2a@NPs, mMSC-TPCS2a@NPs can reduce macrophage uptake by 54% to 70% under different conditions. Both nanoparticle forms are effectively accumulated in MCF7 and MDA-MB-231 breast cancer cells, while uptake in normal breast epithelial cells MCF10A is significantly lower[1].
Product Specifications
CAS Number
2669-65-0
Product Name Alternative
Fimaporfin (free base)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Photosensitizer
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
C1(/C(C(N2)=CC=C2/C(C3=CC=CC=C3)=C4CCC5=N\4)=C6C=CC(/C(C7=CC=CC=C7)=C(N/8)\CCC8=C5\C9=CC=CC=C9)=N/6)=CC=CC=C1
Molecular Formula
C44H34N4
Molecular Weight
618.77
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Mesenchymal Stem Cell Membrane-Coated TPCS2a-Loaded Nanoparticles for Breast Cancer Photodynamic Therapy
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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