Methyl succinate

Methyl succinate is a mitochondrial complex II substrate. Methyl succinate can bypass the inhibition of complex I by Metformin (HY-B0627), restore mitochondrial electron transfer, and reduce AMPK phosphorylation. Methyl succinate is capable of protecting MIN6 β-cells and primary rat β-cells from biguanide-induced toxicity and apoptosis in vitro. Methyl succinate can be used in the research of diseases such as diabetes mellitus[1].

Product Specifications

CAS Number

[3878-55-5]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

AMPK; Apoptosis

Related Pathways

Apoptosis; Epigenetics; PI3K/Akt/mTOR

Field of Research

Metabolic Disease

Concentration

10mM

Purity

99.78

Smiles

O=C(CCC(OC)=O)O

Molecular Formula

C5H8O4

Molecular Weight

132.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Hinke SA, et al. Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. Br J Pharmacol. 2007 Apr;150 (8) :1031-43