4-Chlorophenylacetic acid (Standard)

4-Chlorophenylacetic acid (Standard) is the analytical standard of 4-Chlorophenylacetic acid. This product is intended for research and analytical applications. 4-Chlorophenylacetic acid is a halogenated phenylacetic acid derivative. 4-Chlorophenylacetic acid is a potent aromatase inhibitor and antagonizes estrogen signaling. 4-Chlorophenylacetic acid can provide carbon and energy for Pseudomonas sp. strain CBS3. 4-Chlorophenylacetic acid is effective against estrogen-induced mammary tumorigenesis[1][2].

Product Specifications

CAS Number

[1878-66-6]

UNSPSC

12352005

Target

Cytochrome P450; Drug Derivative; Estrogen Receptor/ERR; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Metabolic Disease

Smiles

OC(=O)CC1=CC=C(Cl)C=C1

Molecular Formula

C8H7ClO2

Molecular Weight

170.59

References & Citations

[1]U Klages, et al. Degradation of 4-chlorophenylacetic Acid by a Pseudomonas Species. J Bacteriol. 1981 Apr;146 (1) :64-8.|[2]Neil Sidell, et al. Inhibition of Estrogen-Induced Mammary Tumor Formation in MMTV-aromatase Transgenic Mice by 4-chlorophenylacetate. Cancer Lett. 2007 Jun 28;251 (2) :302-10.|[3]Aputen, A. D., et al., (2022) . Bioactive Platinum (IV) Complexes Incorporating Halogenated Phenylacetates. Molecules (Basel, Switzerland), 27 (20), 7120.