2-Ethylhexyl diphenyl phosphate

2-Ethylhexyl diphenyl phosphate is an organophosphate flame retardants (OPFRs) and a PPARG agonist (EC20: 2.04 µM) . 2-Ethylhexyl diphenyl phosphate also inhibits ERRγ transcriptional activity (IC50: 1.3 µM) . 2-Ethylhexyl diphenyl phosphate upregulates 3β-HSD1, human chorionic gonadotropin (hCG) and progesterone secretion. 2-Ethylhexyl diphenyl phosphate can be used in studies of female reproduction and fetal development[1][2].

Product Specifications

CAS Number

[1241-94-7]

Product Name Alternative

EHDPP; Octicizer

UNSPSC

12352005

Hazard Statement

H301, H410

Target

Estrogen Receptor/ERR; PPAR; Progesterone Receptor

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Purity

94.27

Smiles

O=P(OC1=CC=CC=C1)(OCC(CC)CCCC)OC2=CC=CC=C2

Molecular Formula

C20H27O4P

Molecular Weight

362.41

Precautions

H301, H410

References & Citations

[1]Hu W, et al. Activation of Peroxisome Proliferator-Activated Receptor Gamma and Disruption of Progesterone Synthesis of 2-Ethylhexyl Diphenyl Phosphate in Human Placental Choriocarcinoma Cells: Comparison with Triphenyl Phosphate. Environ Sci Technol. 2017 Apr 4;51 (7) :4061-4068.|[2]Cao L Y, et al. Organophosphate esters bind to and inhibit estrogen-related receptor γ in cells. Environmental Science & Technology Letters, 2018, 5 (2) : 68-73.