Hydroquinidine (hydrochloride)
Hydroquinidine hydrochloride is a potent ion channel blocker, which exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Hydroquinidine hydrochloride prolongs the QT interval and has antiarrhythmic efficacy[1][2][3][4][5].
Product Specifications
CAS Number
1476-98-8
UNSPSC
12352005
Hazard Statement
H302
Target
Others
Related Pathways
Others
Field of Research
Cancer; Cardiovascular Disease
Smiles
O[C@@H](C1=C(C=C(OC)C=C2)C2=NC=C1)[C@@]3([H])C[C@@]4([H])[C@H](CC)C[N@@]3CC4.Cl
Molecular Formula
C20H27ClN2O2
Molecular Weight
362.90
Precautions
P264-P270-P330-P501
References & Citations
[1]Yavuz M, et al. A potent ion channel blocker, hydroquinidine, exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Mol Biol Rep. 2023 Mar;50 (3) :2611-2621. |[2]Mazzanti A, et al. Hydroquinidine Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome. J Am Coll Cardiol. 2017 Dec 19;70 (24) :3010-3015.|[3]Chimienti M, et al. Comparison of the effectiveness of dihydroquinidine and quinidine on ventricular ectopy after acute and chronic administration. Cardiovasc Drugs Ther. 1988 Dec;2 (5) :679-86.|[4]Hermida JS, et al. Hydroquinidine therapy in Brugada syndrome. J Am Coll Cardiol. 2004 May 19;43 (10) :1853-60.|[5]Mazzanti A, et al. Hydroquinidine Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome. J Am Coll Cardiol. 2017 Dec 19;70 (24) :3010-3015.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
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