Hydroquinidine (hydrochloride)

Hydroquinidine hydrochloride is a potent ion channel blocker, which exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Hydroquinidine hydrochloride prolongs the QT interval and has antiarrhythmic efficacy[1][2][3][4][5].

Product Specifications

CAS Number

[1476-98-8]

UNSPSC

12352005

Hazard Statement

H302

Target

Others

Related Pathways

Others

Field of Research

Cancer; Cardiovascular Disease

Smiles

O[C@@H](C1=C(C=C(OC)C=C2)C2=NC=C1)[C@@]3([H])C[C@@]4([H])[C@H](CC)C[N@@]3CC4.Cl

Molecular Formula

C20H27ClN2O2

Molecular Weight

362.90

Precautions

P264-P270-P330-P501

References & Citations

[1]Yavuz M, et al. A potent ion channel blocker, hydroquinidine, exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Mol Biol Rep. 2023 Mar;50 (3) :2611-2621. |[2]Mazzanti A, et al. Hydroquinidine Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome. J Am Coll Cardiol. 2017 Dec 19;70 (24) :3010-3015.|[3]Chimienti M, et al. Comparison of the effectiveness of dihydroquinidine and quinidine on ventricular ectopy after acute and chronic administration. Cardiovasc Drugs Ther. 1988 Dec;2 (5) :679-86.|[4]Hermida JS, et al. Hydroquinidine therapy in Brugada syndrome. J Am Coll Cardiol. 2004 May 19;43 (10) :1853-60.|[5]Mazzanti A, et al. Hydroquinidine Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome. J Am Coll Cardiol. 2017 Dec 19;70 (24) :3010-3015.