SEW2871 (Standard)
SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses[1][2].
Product Specifications
CAS Number
256414-75-2
UNSPSC
12352005
Target
Akt; ERK; LPL Receptor
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Smiles
FC(C1=CC(C2=NOC(C3=CC(C4=CC=CC=C4)=C(C(F)(F)F)S3)=N2)=CC=C1)(F)F
Molecular Formula
C20H10F6N2OS
Molecular Weight
440.36
References & Citations
[1]Park SJ, et al. Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery. Biomol Ther (Seoul) . 2017 Jan 1;25 (1) :80-90.|[2]Jo E, et al. S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem Biol. 2005 Jun;12 (6) :703-15.|[3]Dong J, et al. Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice. Clin Exp Immunol. 2014 Jul;177 (1) :94-101.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940031-100 1x 100 µL
Mucin 5AC (MUC5AC) (45M1), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400017-500 1x 500 µL
Ep-CAM / CD326 (VU-1D9), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
