Meso-Tetra (4-pyridyl) porphine

Meso-Tetra (4-pyridyl) porphine (Compound 10) is a porphyrin derivative. meso-Tetra (4-pyridyl) porphine is a weak inhibitor of human topoisomerase I (Top1) with an EC50 value greater than 50 µM. meso-Tetra (4-pyridyl) porphine can be used in tumor research[1].

Product Specifications

CAS Number

[16834-13-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Topoisomerase

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

97.0

Smiles

C1(/C2=CC=NC=C2)=C3C=CC(/C(C4=CC=NC=C4)=C5C=C/C(N/5)=C(C6=CC=NC=C6)/C(C=C/7)=NC7=C(C8=CC=NC=C8)/C9=CC=C1N9)=N/3

Molecular Formula

C40H26N8

Molecular Weight

618.70

Precautions

H302, H315, H319, H335

References & Citations

[1]Das SK, et al. Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes. J Med Chem. 2018 Feb 8;61 (3) :804-817.