3-Methylthiophene-2-carboxylic acid
3-Methylthiophene-2-carboxylic acid (compound 3) is a potent Pseudomonas quinolone signal system protein E (PqsE) inhibitor with a Kd of 19.6 µM and an IC50 of 40 µM. 3-Methylthiophene-2-carboxylic acid binds to the active center of PqsE and shows inhibition of the thioesterase activity. Methylthiophene-2-carboxylic acid can permeate into P. aeruginosa and affect 2,4-dihydroxyquinoline (DHQ) levels to a similar extent as deletion of the PqsE gene. 3-Methylthiophene-2-carboxylic acid can be used for cystic fibrosis research[1].
Product Specifications
CAS Number
23806-24-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Inflammation/Immunology
Purity
99.93
Smiles
CC(C=CS1)=C1C(O)=O
Molecular Formula
C6H6O2S
Molecular Weight
142.18
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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