3-Methylthiophene-2-carboxylic acid

3-Methylthiophene-2-carboxylic acid (compound 3) is a potent Pseudomonas quinolone signal system protein E (PqsE) inhibitor with a Kd of 19.6 µM and an IC50 of 40 µM. 3-Methylthiophene-2-carboxylic acid binds to the active center of PqsE and shows inhibition of the thioesterase activity. Methylthiophene-2-carboxylic acid can permeate into P. aeruginosa and affect 2,4-dihydroxyquinoline (DHQ) levels to a similar extent as deletion of the PqsE gene. 3-Methylthiophene-2-carboxylic acid can be used for cystic fibrosis research[1].

Product Specifications

CAS Number

[23806-24-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Inflammation/Immunology

Purity

99.93

Smiles

CC(C=CS1)=C1C(O)=O

Molecular Formula

C6H6O2S

Molecular Weight

142.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Zender M, et al. Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds. ACS Chem Biol. 2016 Jun 17;11 (6) :1755-63.