DMPX

DMPX (3,7-Dimethyl-1-propargylxanthine) is a BBB-penetrable caffeine analogue. DMPX is A2 selective adenosine receptor (AR) antagonist that strongly and selectively blocks hypothermia and behavioral inhibition induced by A2 adenosine receptor agonists such as NECA (HY-103173) . DMPX can be used in the study of Parkinson's disease and other diseases[1][2].

Product Specifications

CAS Number

[14114-46-6]

Product Name Alternative

3,7-Dimethyl-1-propargylxanthine

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Adenosine Receptor

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Concentration

10mM

Purity

99.66

Solubility

DMSO : 40 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N(C)C(N1CC#C)=O)N=CN2C

Molecular Formula

C10H10N4O2

Molecular Weight

218.21

Precautions

H315, H319, H335

References & Citations

[1]Müller CE, et al. Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists. J Med Chem. 1997 Dec 19;40 (26) :4396-405.|[2]Seale TW, et al. 3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs. Life Sci. 1988;43 (21) :1671-84.