5,7-Dichloropyrazolo[1,5-a]pyrimidine

5,7-Dichloropyrazolo[1,5-a]pyrimidine (fragment 5) is a pyrazolopyrimidine phosphodiesterase 10A (PDE10A) inhibitor (Ki=24 μM) . 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used in the study of schizophrenia[1].

Product Specifications

CAS Number

[57489-77-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Purity

99.75

Solubility

DMSO : ≥ 200 mg/mL

Smiles

ClC1=CC(Cl)=NC2=CC=NN21

Molecular Formula

C6H3Cl2N3

Molecular Weight

188.01

Precautions

H302, H315, H319, H335

References & Citations

[1]Raheem IT, et al. Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg Med Chem Lett. 2016 Jan 1;26 (1) :126-32.