5,7-Dichloropyrazolo[1,5-a]pyrimidine
5,7-Dichloropyrazolo[1,5-a]pyrimidine (fragment 5) is a pyrazolopyrimidine phosphodiesterase 10A (PDE10A) inhibitor (Ki=24 μM) . 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used in the study of schizophrenia[1].
Product Specifications
CAS Number
[57489-77-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Purity
99.75
Solubility
DMSO : ≥ 200 mg/mL
Smiles
ClC1=CC(Cl)=NC2=CC=NN21
Molecular Formula
C6H3Cl2N3
Molecular Weight
188.01
Precautions
H302, H315, H319, H335
References & Citations
[1]Raheem IT, et al. Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg Med Chem Lett. 2016 Jan 1;26 (1) :126-32.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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