O6-Benzylguanine (Standard)
O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity[1][2].
Product Specifications
CAS Number
19916-73-5
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
NC(N=C1OCC2=CC=CC=C2)=NC3=C1NC=N3
Molecular Formula
C12H11N5O
Molecular Weight
241.25
References & Citations
[1]Rabik CA, Njoku MC, Dolan ME. Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy. Cancer Treat Rev. 2006;32 (4) :261‐276.|[2]Konduri, Santhi D et al. Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research vol. 15,19 (2009) : 6087-95.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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