7-Methoxy-1-tetralone

7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2) /MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index[1].

Product Specifications

CAS Number

[6836-19-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H332, H335

Target

Akt; Apoptosis; c-Met/HGFR; MMP; NF-κB

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CCC1)C2=C1C=CC(OC)=C2

Molecular Formula

C11H12O2

Molecular Weight

176.22

Precautions

H302, H315, H319, H332, H335

References & Citations

[1]Wen Y, et al. 7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-κB, MMP2, and MMP9 Expression. Front Oncol. 2020 Feb 7;10:58.