EF-5 (Standard)

EF-5 (EF5; 2-Nitroimidazole) is a hypoxia labeling agent used to identify hypoxia in cells.

Product Specifications

CAS Number

[152721-37-4]

UNSPSC

12352005

Target

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Cancer

Smiles

O=C(NCC(F)(F)C(F)(F)F)CN1C=CN=C1[N+]([O-])=O

Molecular Formula

C8H7F5N4O3

Molecular Weight

302.16

References & Citations

[1]Wang J, et al. The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia. Clin Cancer Res. 2012 Mar 15;18 (6) :1684-95.|[2]Evans SM, et al. Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2- (2-nitro-1H-imidazol-1-yl) -N- (2,2,3,3,3-pentafluoropropyl) acetamide]. Br J Cancer. 1995 Oct;72 (4) :875-82.