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DXR-IN-3

DXR-IN-3 is a DXR inhibitor that specifically targets Toxoplasma gondii. DXR-IN-3 shows in vitro activity against the TgDXR enzyme, with an IC50 value of 0.62 μM and a Ki value of 0.19 μM. DXR-IN-3 can inhibit the proliferation of Toxoplasma, with an IC50 value of 5.46 μM[1].

Product Specifications

CAS Number

1465907-72-5

UNSPSC

12352101

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dxr-in-3.html

Smiles

O=C(N(C)O)CSC(P(O)(O)=O)C1=CC(Cl)=C(Cl)C=C1

Molecular Formula

C10H12Cl2NO5PS

Molecular Weight

360.15

References & Citations

[1]Mazzone F, et al. 1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors. Biochem J. 2024 Aug 21;481 (16) :1075-1096.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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