Icariside D2

Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC50 value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis [1][2].

Product Specifications

CAS Number

[38954-02-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin-converting Enzyme (ACE) ; Apoptosis; HIV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/icariside-d2.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@H](OC2=CC=C(CCO)C=C2)O[C@H](CO)[C@@H](O)[C@@H]1O

Molecular Formula

C14H20O7

Molecular Weight

300.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Nguyen Thi Thu Hien, et al. Chemical Constituents of the Annona Glabra Fruit and Their Cytotoxic Activity. Pharm Biol. 2015;53 (11) :1602-7.|[2]Xue Liu, et al. Metabolic Engineering Escherichia coli for Efficient Production of Icariside D2. Biotechnol Biofuels. 2019 Nov 6;12:261.|[3]Jin-YuLi, et al. Three new acylated prenylflavonol glycosides from Epimedium koreanum. Phytochemistry Letters Volume 17, September 2016, Pages 206-212.