Englerin A
Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload[1][2][3].
Product Specifications
CAS Number
1094250-15-3
UNSPSC
12352005
Target
TRP Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/englerin-a.html
Purity
99.50
Solubility
DMSO : 50 mg/mL|Methanol : 30 mg/mL (ultrasonic)
Smiles
O=C(O[C@@H]1[C@]2(C(C)C)C[C@@H](OC(CO)=O)[C@](O2)(C)[C@]3([H])CC[C@@H](C)[C@@]13[H])/C=C/C4=CC=CC=C4
Molecular Formula
C26H34O6
Molecular Weight
442.54
References & Citations
[1]Akbulut Y, et, al. (-) -Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl. 2015 Mar 16;54 (12) :3787-91.|[2]Rubaiy HN, et, al. Identification of an (-) -englerin A analogue, which antagonizes (-) -englerin A at TRPC1/4/5 channels. Br J Pharmacol. 2018 Mar; 175 (5) :830-839.|[3]Carson C, et, al. Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation. PLoS One. 2015 Jun 22;10 (6) :e0127498.|[4]Sourbier C, et, al. Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality. Cancer Cell. 2013 Feb 11;23 (2) :228-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
TRPC4; TRPC5
Available Sizes
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