Human Sonic Hedgehog (C24II), Tag Free, HEK293

<strong>Human Sonic Hedgehog (C24II), Tag Free, HEK293</strong>_x000D_ <strong>Catalog number:</strong> B2018851_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> ~20 kDa_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20¬∞C_x000D_ <strong>Keywords:</strong> Human Sonic Hedgehog (C24II), Tag Free, HEK293_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Fu B, Liu W, Zhu C, Li P, Wang L, Pan L, Li K, Cai P, Meng M, Wang Y, Zhang A, Tang W, An M. Circular RNA circBCBM1 promotes breast cancer brain metastasis by modulating miR-125a/BRD4 axis Int J Biol Sci. 2021 Jul 22;17(12):3104-3117._x000D_ 2: Bonilla X, Parmentier L, King B, Bezrukov F, Kaya G, Zoete V, Seplyarskiy VB, Sharpe HJ, McKee T, Letourneau A, Ribaux PG, Popadin K, Basset-Seguin N, Ben Chaabene R, Santoni FA, Andrianova MA, Guipponi M, Garieri M, Verdan C, Grosdemange K, Sumara O, Eilers M, Aifantis I, Michielin O, de Sauvage FJ, Antonarakis SE, Nikolaev SI. Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma Nat Genet. 2016 Apr;48(4):398-406._x000D_ 3: Niu C, Chen Z, Kim KT, Sun J, Xue M, Chen G, Li S, Shen Y, Zhu Z, Wang X, Liang J, Jiang C, Cong W, Jin L, Li X. Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway Autophagy. 2019 May;15(5):843-870._x000D_ 4: Coupland CE, Andrei SA, Ansell TB, Carrique L, Kumar P, Sefer L, Schwab RA, Byrne EFX, Pardon E, Steyaert J, Magee AI, Lanyon-Hogg T, Sansom MSP, Tate EW, Siebold C. Structure, mechanism, and inhibition of Hedgehog acyltransferase Mol Cell. 2021 Dec 16;81(24):5025-5038.e10._x000D_ 5: Wierbowski BM, Petrov K, Aravena L, Gu G, Xu Y, Salic A. Hedgehog Pathway Activation Requires Coreceptor-Catalyzed, Lipid-Dependent Relay of the Sonic Hedgehog Ligand Dev Cell. 2020 Nov 23;55(4):450-467.e8._x000D_ 6: Koso H, Tsuhako A, Lyons E, Ward JM, Rust AG, Adams DJ, Jenkins NA, Copeland NG, Watanabe S. Identification of FoxR2 as an oncogene in medulloblastoma Cancer Res. 2014 Apr 15;74(8):2351-61._x000D_ 7: Lin YC, Roffler SR, Yan YT, Yang RB. Disruption of Scube2 Impairs Endochondral Bone Formation J Bone Miner Res. 2015 Jul;30(7):1255-67._x000D_ 8: Su Y, Yuan Y, Feng S, Ma S, Wang Y. High frequency stimulation induces sonic hedgehog release from hippocampal neurons Sci Rep. 2017 Mar 6;7:43865._x000D_ 9: Yao PJ, Manor U, Petralia RS, Brose RD, Wu RT, Ott C, Wang YX, Charnoff A, Lippincott-Schwartz J, Mattson MP. Sonic hedgehog pathway activation increases mitochondrial abundance and activity in hippocampal neurons Mol Biol Cell. 2017 Feb 1;28(3):387-395._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/28473325">10: Trempus CS, Song W, Lazrak A, Yu Z, Creighton JR, Young BM, Heise RL, Yu YR, Ingram JL, Tighe RM, Matalon S, Garantziotis S. A novel role for primary cilia in airway remodeling Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L328-L338. </a>_x000D_ _x000D_ <strong>Products Related to Human Sonic Hedgehog (C24II), Tag Free, HEK293 can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>