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Crizanlizumab (anti-P-selectin)

Crizanlizumab (anti-P-selectin) is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1) . Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease[1][2][3].

Product Specifications

CAS Number

[1690318-25-2]

UNSPSC

12352203

Target

P-selectin

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

[Crizanlizumab(anti-P-selectin)]

References & Citations

[1]Hannah A. Blair, et al. Crizanlizumab: First Approval. Drugs. 80, 79-84 (2020) . |[2]Ataga KI, et al. Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease. N Engl J Med. 2017 Feb 2;376 (5) :429-439.|[3]Ravirajsinh Jadeja, et al. Therapeutic potential of Crizanlizumab (anti-P-selectin) in improving sickle cell retinopathy in mice. Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4747.

Shipping Conditions

Room temperature

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Curated Selection

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