Nogapendekin alfa (his tag)

Nogapendekin alfa (his tag), a soluble protein subunit of a human interleukin (IL) -15 variant, is a superagonist of IL-15. Nogapendekin alfa (his tag) promotes the proliferation and viability of immune cells. Nogapendekin alfa (his tag) combines with Inbakicept (HY-P99661) at a ratio of 2:1, to form N-803 (Nogapendekin alfa inbakicept), an IL-15 cytokine antibody fusion protein. N-803 reduces tumor burden by activation of NK cells and CD8+ T cells[1].

Product Specifications

CAS Number

[1622189-43-8]

Product Name Alternative

IL-15N72D

UNSPSC

12352203

Target

Interleukin Related

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Purity

98.62

Solubility

10 mM in DMSO

Smiles

[Nogapendekinalfa(histag)]

Molecular Weight

(13.91 kDa)

References & Citations

[1]Chen W, et al. ALT-803 in the treatment of non-muscle-invasive bladder cancer: Preclinical and clinical evidence and translational potential. Front Immunol. 2022 Nov 10;13:1040669.