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Vorsetuzumab mafodotin

Vorsetuzumab mafodotin (SGN-75) is an Auristatin-based anti-CD70 antibody-drug conjugate (ADC) . Vorsetuzumab mafodotin consists of a humanized monoclonal antibody, Vorsetuzumab and an ADC cytotoxin MMAF. Vorsetuzumab mafodotin has antineoplastic activity[1].

Product Specifications

CAS Number

1165741-01-4

Product Name Alternative

Anti-Human CD70 Recombinant Antibody; SGN-75

UNSPSC

12352203

Target

Antibody-Drug Conjugates (ADCs) ; Microtubule/Tubulin

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.69

Solubility

10 mM in DMSO

Smiles

[Vorsetuzumabmafodotin]

Molecular Weight

(150 kDa)

References & Citations

[1]M C Ryan, et al. Targeting pancreatic and ovarian carcinomas using the auristatin-based anti-CD70 antibody-drug conjugate SGN-75. Br J Cancer. 2010 Aug 24;103 (5) :676-84.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C, protect from light

Scientific Category

ADC Related

Clinical Information

Phase 1

Available Sizes

Frequently Asked Questions

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