VHB937
VHB937 is a potent and selective TREM2 agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as Syk phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research[1].
Product Specifications
UNSPSC
12352211
Target
Calcium Channel; Syk; TREM receptor
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
99.9
References & Citations
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Isoform
TREM-2
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD16 (C16/1045), CF640R conjugate, 0.1mg/mL
NGFR (Nerve Growth Factor Receptor) (NGFR5), CF647 conjugate, 0.1mg/mL
