IGN523

IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM) . IGN523 induces antibody-dependent cell-mediated cytotoxicity (ADCC) activity, lysosomal membrane permeabilization, and inhibition of essential amino acid transport, ultimately leading to caspase-3 and caspase-7-mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in multiple tumor xenograft models. IGN523 is useful in the research of non-small cell lung cancer (NSCLC), acute myeloid leukemia (AML), and other cancers.[1].

Product Specifications

Product Name Alternative

AML-01

UNSPSC

12352100

Target

Apoptosis; Caspase

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

References & Citations

[1]Hayes GM, Chinn L, Cantor JM, Cairns B, Levashova Z, Tran H, Velilla T, Duey D, Lippincott J, Zachwieja J, Ginsberg MH, H van der Horst E. Antitumor activity of an anti-CD98 antibody. Int J Cancer. 2015 Aug 1;137 (3) :710-20.