IGN523
IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM) . IGN523 induces antibody-dependent cell-mediated cytotoxicity (ADCC) activity, lysosomal membrane permeabilization, and inhibition of essential amino acid transport, ultimately leading to caspase-3 and caspase-7-mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in multiple tumor xenograft models. IGN523 is useful in the research of non-small cell lung cancer (NSCLC), acute myeloid leukemia (AML), and other cancers.[1].
Product Specifications
Product Name Alternative
AML-01
UNSPSC
12352100
Target
Apoptosis; Caspase
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
References & Citations
[1]Hayes GM, Chinn L, Cantor JM, Cairns B, Levashova Z, Tran H, Velilla T, Duey D, Lippincott J, Zachwieja J, Ginsberg MH, H van der Horst E. Antitumor activity of an anti-CD98 antibody. Int J Cancer. 2015 Aug 1;137 (3) :710-20.
Shipping Conditions
Dry Ice
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 7
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