AG01
AG01 is a monoclonal antibody against progranulin (GP88) . AG01 inhibits triple-negative breast cancer (TNBC) cell proliferation and migration, reduces the expression of phosphorylated protein kinases p-Src, p-AKT, and p-ERK, and reduces the expression of oncogenic proteins such as Axl, c-MET, HIF-1α, and VEGF. AG01 inhibits tumor growth and Ki67 expression in a TNBC xenograft mouse model. AG01 can be used in the research of TNBC and other cancers[1].
Product Specifications
UNSPSC
12352100
Target
Akt; c-Met/HGFR; ERK; HIF/HIF Prolyl-Hydroxylase; MMP; Src; TAM Receptor; VEGFR
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P991664/
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Isoform
Axl; ERK1; ERK2; HIF-1α; MMP-2
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