REGN7999
REGN7999 is a monoclonal antibody that inhibits TMPRSS6. REGN7999 inhibits TMPRSS6 activity, preventing Hemojuvelin (HJV) lysis, thereby enhancing BMP6-HJV signaling and increasing serum hepcidin. REGN7999 ameliorates iron overload and impaired erythropoiesis in a β-thalassemia mouse model by inhibiting TMPRSS6 activity. REGN7999 is indicated for research in β-thalassemia[1][2].
Product Specifications
UNSPSC
12352100
Target
Ser/Thr Protease
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
References & Citations
[1]Lob, et al. Economides, Aris1; Hatsell, Sarah1. S281: TMPRSS6 INHIBITION WITH A MONOCLONAL ANTIBODY IMPROVES RED BLOOD CELL HEALTH AND IRON OVERLOAD IN A MOUSE MODEL OF BETA-THALASSEMIA. HemaSphere 7 (S3) :p e4989627, August 2023. |[2]Lob HE, et al. A TMPRSS6-inhibiting mAb improves disease in a β-thalassemia mouse model and reduces iron in healthy humans. JCI Insight. 2025 Jun 23;10 (12) :e191813.
Shipping Conditions
Room temperature
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
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