RFB4
RFB4 is a anti-CD22 monoclonal antibody. RFB4 can construct recombinant immunotoxins by fusing with copper green pseudomonas exotoxin (PE38) through disulfide bonds such as RFB4 (dsFv) -PE38. RFB4 can be used for research on cancer such as lymphoma[1][2].
Product Specifications
CAS Number
505393-48-6
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
CD22
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
96.93
Precautions
H302, H315, H319, H335
References & Citations
[1]Mansfield E, et al. Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors. Blood. 1997 Sep 1;90 (5) :2020-6.|[2]Kreitman RJ, et al. Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4 (dsFv) -PE38 at doses tolerated by cynomolgus monkeys. Int J Cancer. 1999 Mar 31;81 (1) :148-55.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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