RFB4

RFB4 is a anti-CD22 monoclonal antibody. RFB4 can construct recombinant immunotoxins by fusing with copper green pseudomonas exotoxin (PE38) through disulfide bonds such as RFB4 (dsFv) -PE38. RFB4 can be used for research on cancer such as lymphoma[1][2].

Product Specifications

CAS Number

[505393-48-6]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

CD22

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

96.93

Precautions

H302, H315, H319, H335

References & Citations

[1]Mansfield E, et al. Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors. Blood. 1997 Sep 1;90 (5) :2020-6.|[2]Kreitman RJ, et al. Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4 (dsFv) -PE38 at doses tolerated by cynomolgus monkeys. Int J Cancer. 1999 Mar 31;81 (1) :148-55.