PF-04382923
PF-04382923 is a humanized IgG2Δa monoclonal antibody. PF-04382923 binds with high affinity to the free C-terminal regions of the amyloid-β peptides Aβ1-40 and Aβ1-42. PF-04382923 is indicated for the study of geographic atrophy (GA) associated with dry age-related macular degeneration (ARMD) [1].
Product Specifications
UNSPSC
12352211
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
References & Citations
[1]Liao K, et al. A Mechanism-Based Binding Model for the Pharmacokinetics and Pharmacodynamics (PK-PD) of RN6G (PF-04382923), a Humanized Monoclonal Antibody against Amyloid β Peptides, in Subjects with Dry, Age-Related Macular Degeneration Including Geographic Atrophy[J]. Investigative Ophthalmology & Visual Science, 2013, 54 (15) : 3287-3287.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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