AGEN-2373
AGEN-2373 is a conditionally active agonist antibody targeting the co-stimulatory receptor CD137. GEN-2373 binds to CD137 without disruption of ligand binding. AGEN-2373 stimulates CD137 under receptor clustering conditions. AGEN-2373 can enhance T cell activity when combined with other checkpoint modulators (e.g. PD-1 antagonist and OX40 agonist) . AGEN-2373 can be studied in research for human malignancies[1].
Product Specifications
UNSPSC
12352203
Target
TNF Receptor
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
References & Citations
[1]Claire Galand, et al., AGEN2373 is a conditionally-active agonist antibody targeting the co-stimulatory receptor CD137 for the treatment of human malignancies. Journal of Clinical Oncology, 2019.
Shipping Conditions
Room temperature
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1475159-01 0.02 mg (E-Coli)
Recombinant Escherichia coli O157:H7 Probable transcriptional regulatory protein YeeN (yeeN)
Ask
View Details 
MBS1475159-02 0.1 mg (E-Coli)
Recombinant Escherichia coli O157:H7 Probable transcriptional regulatory protein YeeN (yeeN)
Ask
View Details MBS1475159-03 0.02 mg (Yeast)
Recombinant Escherichia coli O157:H7 Probable transcriptional regulatory protein YeeN (yeeN)
Ask
View Details MBS1475159-04 0.1 mg (Yeast)
Recombinant Escherichia coli O157:H7 Probable transcriptional regulatory protein YeeN (yeeN)
Ask
View Details