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CDX-1140

CDX-1140 is a human IgG2 CD40 agonist antibody. CDX-1140 activates dendritic cells (DCs) and B cells and drives NF-kB stimulation in a CD40-expressing reporter cell line. CDX-1140 is independent of FcR binding and synergistic with native CD40L signaling. CDX-1140 has both direct and immune-mediated anti-tumor activity. CDX-1140 can be used for the study of lymphoma cancer and solid tumors[1][2].

Product Specifications

UNSPSC

12352203

Target

TNF Receptor

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

References & Citations

[1]Vitale LA, et al. Development of CDX-1140, an agonist CD40 antibody for cancer immunotherapy. Cancer Immunol Immunother. 2019 Feb;68 (2) :233-245.

Shipping Conditions

Room temperature

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Frequently Asked Questions

More Discoveries

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