NP137
NP137 is a human IgG1 monoclonal antibody (mAb) targeting Netrin-1. NP137 inhibits the binding of netrin-1 to its receptor UNC5H2 (IC50: 0.5 nM) . NP137 activates caspase 3 to induce apoptosis. NP137 can be used in solid tumors and hematologic malignancies research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) [1].
Product Specifications
UNSPSC
12352203
Target
Apoptosis
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.58
Smiles
[NP137]
Molecular Weight
(144.60 kDa)
References & Citations
[1]Ducarouge B, et al. Preclinical characteristics of NP137, a first-in-class monoclonal antibody directed against netrin-1 and inducing dependence receptors-mediated cell death[J]. Cancer Research, 2015, 75 (15_Supplement) : 2921-2921.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P991427/NP137-SDS-MedChemExpress.pdf
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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