MB-314

MB-314 is a human IgG1 monoclonal antibody (mAb) targeting Lewis Y. MB-314 induces enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. MB-314 increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 can be used in cancer research[1].

Product Specifications

UNSPSC

12352203

Target

IFNAR; TNF Receptor; Transmembrane Glycoprotein

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

[MB-314]

References & Citations

[1]Kircheis R, et al. Correlation of ADCC activity with cytokine release induced by the stably expressed, glyco-engineered humanized Lewis Y-specific monoclonal antibody MB314. MAbs. 2012 Jul-Aug;4 (4) :532-41.